Table 4.

Twenty-eight enriched hallmarks from MSigDB based on the TAA score

Gene sets	setSize	EScore	NES	p.adjust	qvalues
Cancer hallmark
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	103	0.5295	1.858	0.0041	0.0016
HALLMARK_DNA_REPAIR	24	0.5277	1.5782	0.0164	0.0063
HALLMARK_ANGIOGENESIS	20	0.526	1.5274	0.0199	0.0077
HALLMARK_HYPOXIA	64	0.5154	1.741	0.0041	0.0016
HALLMARK_G2M_CHECKPOINT	28	0.4878	1.4996	0.029	0.0112
HALLMARK_APOPTOSIS	72	0.4327	1.4798	0.0057	0.0022
Oncogene-related gene sets
HALLMARK_MYC_TARGETS_V1	20	0.5697	1.6542	0.0074	0.0028
HALLMARK_MTORC1_SIGNALING	63	0.5487	1.8521	0.0041	0.0016
HALLMARK_P53_PATHWAY	80	0.4749	1.6378	0.0041	0.0016
HALLMARK_TNFA_SIGNALING_VIA_NFKB	77	0.4206	1.4456	0.0093	0.0036
HALLMARK_IL2_STAT5_SIGNALING	117	0.3690	1.3093	0.0149	0.0058
HALLMARK_KRAS_SIGNALING_UP	93	0.3662	1.2778	0.0385	0.0149
Metabolism-related gene sets
HALLMARK_GLYCOLYSIS	56	0.5345	1.7832	0.0041	0.0016
HALLMARK_FATTY_ACID_METABOLISM	43	0.5288	1.7184	0.0041	0.0016
HALLMARK_CHOLESTEROL_HOMEOSTASIS	37	0.5179	1.6517	0.0058	0.0022
HALLMARK_XENOBIOTIC_METABOLISM	70	0.4363	1.4881	0.0058	0.0022
Immune-related gene sets
HALLMARK_INTERFERON_ALPHA_RESPONSE	29	0.5278	1.6292	0.0058	0.0022
HALLMARK_TNFA_SIGNALING_VIA_NFKB	77	0.4206	1.4456	0.0093	0.0036
HALLMARK_INTERFERON_GAMMA_RESPONSE	78	0.4098	1.4103	0.0111	0.0043
HALLMARK_ALLOGRAFT_REJECTION	117	0.3988	1.4151	0.0041	0.0016
HALLMARK_COMPLEMENT	109	0.3663	1.2927	0.0207	0.0080
Hormone-related gene sets
HALLMARK_ESTROGEN_RESPONSE_LATE	83	0.5719	1.9798	0.0041	0.0016
HALLMARK_ESTROGEN_RESPONSE_EARLY	90	0.5408	1.8812	0.0041	0.0016
HALLMARK_ANDROGEN_RESPONSE	44	0.4771	1.5572	0.0075	0.0029
Damage response-related gene sets
HALLMARK_UNFOLDED_PROTEIN_RESPONSE	21	0.6475	1.8899	0.0041	0.0016
HALLMARK_UV_RESPONSE_UP	60	0.4470	1.4992	0.0058	0.0022
Environment-related gene sets
HALLMARK_APICAL_SURFACE	39	0.5026	1.6139	0.0075	0.0029
HALLMARK_COAGULATION	75	0.4896	1.6791	0.0041	0.0016
HALLMARK_PROTEIN_SECRETION	44	0.5000	1.6320	0.0041	0.0016