Table 1. PAA-BP-metal coordination bonding enables thiol-based covalent attachment of Ad-binding agents for tethering Ad: Ad-binding comparisons of various alloys and D1 vs. antibody (mean ± SE).
Metal alloy | Anti-knob antibody-bound Ad (×109 particles per cm2) | D1-bound Ad (×109 particles per cm2) |
---|---|---|
316L steel | 4.30 ± 0.34 | 10.8 ± 0.6* |
Nitinol | 5.27 ± 0.10 | 11.6 ± 0.4* |
Co—Cr | 3.52 ± 1.13 | 15.1 ± 1.37* |
Greater binding with D1, P < 0.001.