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Packing interfaces between LRs and SRs. (A) Stereoscopic view of key residues forming the LR:SR2, SR2:SR3, and SR3:SR4 hydrophobic packing interfaces. The backbone traces of LR and SR2 are drawn in a cartoon representation. (B) Stereoscopic view of the hydrogen-bonding network formed at the interface between the LR and preceding SR in TcdA-f1. The highly conserved residues forming hydrogen bonds (dashed lines) are highlighted in both the primary and tertiary structure diagrams.
