Fig. 1.

Widespread twi/CNP-EGFP grafts in the shi mouse brain 4 months after transplantation. Extensive distribution of twi mutant OLs/myelin in coronal (A) and sagittal (B) sections of shi brains revealed by EGFP signal (green), MBP immunolabeling (red), and their merged images. (C-E) Merged images of CNP-EGFP and MBP immunolabeling. (C) The twi/CNP-EGFP OL-derived myelination extending toward the ventral part of the external capsule at the midbrain level, showing long-distance migration of donor cells. The grafts were also found in areas distant from the injection sites, such as optic chiasm (D) and cerebellar white matter (E). C and D are coronal sections, and E is a sagittal section. [Scale bars: 500 μm (A-C) and 200 μm (D and E).]