Figure 1.

Effect of TGF-β1 and FCS on collagen gel contraction mediated by HFL-1 cells. Fibroblast-populated collagen gels were released into 60 mm tissue culture dishes with or without FCS or TGF-β1. Gel size was measured daily with an image analyzer. Vertical axis: gel size expressed as % of initial size. Horizontal axis: Time (days of culture). Both serum and TGF-β1 significantly augmented collagen gel contraction in a concentration-dependent manner. *p < 0.05 as compared with control. Data are shown as means ± SEM. Data presented are from one representative experiment of three experiments performed on separate occasions.