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. Author manuscript; available in PMC: 2026 May 20.
Published in final edited form as: Nanomedicine. 2025 Apr 30;67:102825. doi: 10.1016/j.nano.2025.102825

Fig. 1.

Fig. 1.

Synthetic schematic of MATCH nanoconjugates. (A) Synthetic scheme of generating Fab′-MORF conjugates from whole antibody starting material. (B) Linker coupling of 3′-amine functionalized morpholino oligonucleotides using a bifunctional ethylene glycol dimer. (C) Hybridization of two complementary Fab′-MORF conjugates. Conventionally, Fab′-MORF1 conjugates are B-cell engagers and Fab′-MORF2 conjugates are T-cell engagers. (D) Chemical structure of bifunctional oligoethylene glycol (PEG) linker. (E) Size exclusion chromatogram overlay of Fab′CD20-MORF1 (blue), Fab′CD19-MORF1 (red), and Fab′CD3-MORF2 (green) products used in this study. Chromatographs were detected on a Superdex 200 10/300 GL column in PBS (pH 7.4) at 0.4 mL min−1.