. 2026 May 7;17:1786548. doi: 10.3389/fneur.2026.1786548

Table 2.

Regional cortical thickness comparisons between DOC patients and healthy controls.

Brain region	Hemisphere	Mean DOC (mm)	Mean HC (mm)	T statistic	p value	Sig
Bankssts	lh	2.160	2.495	−5.201	0.001	**
Bankssts	rh	2.260	2.612	−6.936	<0.001	***
Caudal anterior cingulate	lh	1.863	2.401	−7.582	<0.001	***
Caudal anterior cingulate	rh	1.825	2.422	−8.813	<0.001	***
Caudal middle frontal	lh	2.219	2.626	−7.560	<0.001	***
Caudal middle frontal	rh	2.265	2.620	−7.231	<0.001	***
Cuneus	lh	1.796	1.927	−3.059	0.255
Cuneus	rh	1.793	1.999	−4.316	0.007	**
Entorhinal	lh	2.145	2.607	−4.138	0.011	*
Entorhinal	rh	1.922	2.530	−4.841	0.001	**
Frontal pole	lh	2.128	2.785	−9.355	<0.001	***
Frontal pole	rh	2.053	2.739	−11.112	<0.001	***
Fusiform	lh	2.033	2.522	−7.671	<0.001	***
Fusiform	rh	2.024	2.454	−6.945	<0.001	***
Inferior parietal	lh	2.170	2.495	−4.961	0.002	**
Inferior parietal	rh	2.235	2.484	−4.697	0.004	**
Inferior temporal	lh	2.141	2.697	−6.887	<0.001	***
Inferior temporal	rh	2.320	2.728	−5.875	<0.001	***
Insula	lh	2.189	3.141	−8.441	<0.001	***
Insula	rh	2.316	3.218	−9.791	<0.001	***
Isthmus cingulate	lh	1.783	2.100	−5.662	<0.001	***
Isthmus cingulate	rh	1.765	2.060	−5.382	<0.001	***
Lateral occipital	lh	1.875	2.211	−5.777	<0.001	***
Lateral occipital	rh	1.918	2.229	−5.536	<0.001	***
Lateral orbitofrontal	lh	2.164	2.746	−9.310	<0.001	***
Lateral orbitofrontal	rh	2.117	2.757	−11.910	<0.001	***
Lingual	lh	1.715	1.991	−6.659	<0.001	***
Lingual	rh	1.706	2.002	−7.210	<0.001	***
Medial orbitofrontal	lh	2.031	2.505	−9.973	<0.001	***
Medial orbitofrontal	rh	2.009	2.567	−11.341	<0.001	***
Middle temporal	lh	2.230	2.785	−6.431	<0.001	***
Middle temporal	rh	2.437	2.836	−6.884	<0.001	***
Paracentral	lh	2.121	2.303	−3.268	0.153
Paracentral	rh	2.125	2.376	−4.068	0.018	*
Parahippocampal	lh	1.268	1.796	−7.517	<0.001	***
Parahippocampal	rh	1.368	1.838	−5.571	<0.001	***
Pars opercularis	lh	2.122	2.677	−7.750	<0.001	***
Pars opercularis	rh	2.212	2.673	−9.165	<0.001	***
Pars orbitalis	lh	2.176	2.738	−8.420	<0.001	***
Pars orbitalis	rh	2.200	2.736	−8.568	<0.001	***
Pars triangularis	lh	1.994	2.563	−10.012	<0.001	***
Pars triangularis	rh	2.080	2.611	−11.252	<0.001	***
Pericalcarine	lh	1.526	1.599	−1.626	1.000
Pericalcarine	rh	1.523	1.718	−4.994	0.001	***
Postcentral	lh	1.853	2.102	−4.142	0.014	*
Postcentral	rh	1.891	2.099	−4.334	0.006	**
Posterior cingulate	lh	1.967	2.312	−7.241	<0.001	***
Posterior cingulate	rh	1.919	2.336	−8.020	<0.001	***
Precentral	lh	2.030	2.345	−5.214	0.001	***
Precentral	rh	2.074	2.313	−4.240	0.011	*
Precuneus	lh	2.161	2.392	−5.113	0.001	***
Precuneus	rh	2.193	2.420	−4.553	0.005	**
Rostral anterior cingulate	lh	2.011	2.703	−10.489	<0.001	***
Rostral anterior cingulate	rh	2.054	2.700	−9.780	<0.001	***
Rostral middle frontal	lh	2.012	2.509	−10.135	<0.001	***
Rostral middle frontal	rh	1.964	2.512	−11.553	<0.001	***
Superior frontal	lh	2.325	2.809	−9.238	<0.001	***
Superior frontal	rh	2.285	2.844	−9.735	<0.001	***
Superior parietal	lh	2.105	2.295	−3.656	0.057
Superior parietal	rh	2.123	2.273	−3.106	0.274
Superior temporal	lh	2.157	2.750	−8.117	<0.001	***
Superior temporal	rh	2.304	2.869	−10.163	<0.001	***
Supramarginal	lh	2.130	2.520	−5.662	<0.001	***
Supramarginal	rh	2.211	2.499	−5.899	<0.001	***
Temporal pole	lh	2.837	3.613	−5.544	<0.001	***
Temporal pole	rh	2.909	3.796	−7.237	<0.001	***
Transverse temporal	lh	1.903	2.270	−6.198	<0.001	***
Transverse temporal	rh	1.977	2.333	−5.329	<0.001	***

Regional cortical thickness measurements (in millimeters) for all Desikan–Killiany atlas regions. Statistical comparisons performed using Mann–Whitney U tests with Bonferroni correction for multiple comparisons. Significance levels: *p < 0.05, **p < 0.01, ***p < 0.001. lh = left hemisphere; rh = right hemisphere; DOC = disorders of consciousness; HC = healthy controls; p value = Bonferroni-adjusted p-value.