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. 2026 Mar 25;15(4):332. doi: 10.21037/tcr-2026-1-0320

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Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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EBV DNA response patterns and association with survival outcomes. (A) Plasma EBV DNA clearance status distributed across nodal response groups (CR vs. non-CR), with a higher clearance rate observed in the CR group. (B-E) EBV DNA clearance after IC was associated with better PFS (B), OS (C), LRRFS (D), and DMFS (E) compared to non-clearance. CI, confidence interval; CR, complete response; DMFS, distant metastasis-free survival; EBV, Epstein-Barr virus; HR, hazard ratio; IC, induction chemotherapy; LRRFS, locoregional relapse-free survival; OS, overall survival; PFS, progression-free survival.