Table 2. Survival outcomes associated with EBV DNA non-clearance at different timepoints.
| Endpoint | Post-IC EBV non-clearance | Non-clearance within 12 months | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| PFS | 3.91 (2.19–6.97) | <0.001 | 9.30 (5.20–16.65) | <0.001 | |
| OS | 4.10 (1.06–15.88) | 0.041 | 30.64 (3.88–241.86) | 0.001 | |
| DMFS | 3.02 (1.42–6.45) | 0.004 | 8.65 (3.91–19.13) | <0.001 | |
| LRRFS | 4.44 (1.83–10.80) | 0.001 | 6.85 (2.90–16.17) | <0.001 | |
CI, confidence interval; DMFS, distant metastasis-free survival; EBV, Epstein-Barr virus; HR, hazard ratio; IC, induction chemotherapy; LRRFS, locoregional relapse-free survival; OS, overall survival; PFS, progression-free survival.