Table 2.

IC₅₀ values of compounds 5a-t against SH-SY5Y and HUVEC cell lines and selectivity indices (SI).

Compounds	IC50 (µM)*		Selectivity Index (SI)**
	SH-SY5Y	HUVEC
5a	14.02 ± 1.05	38.06 ± 2.65	2.7
5b	8.69 ± 0.92	22.20 ± 2.11	2.6
5c	20.00 ± 1.95	31.90 ± 2.37	1.6
5d	9.19 ± 1.35	40.62 ± 2.96	4.4
5e	18.08 ± 2.14	36.39 ± 3.42	2.0
5f	12.32 ± 1.53	50.43 ± 4.15	4.1
5g	15.74 ± 1.67	42.82 ± 4.57	2.7
5h	7.22 ± 0.88	42.23 ± 3.78	5.8
5i	18.43 ± 1.29	44.44 ± 3.65	2.4
5j	14.47 ± 1.22	30.08 ± 3.18	2.1
5k	19.77 ± 1.65	39.74 ± 3.49	2.0
5l	9.70 ± 0.92	50.37 ± 4.21	5.2
5m	8.39 ± 1.51	47.73 ± 3.15	5.7
5n	5.23 ± 0.78	44.89 ± 4.32	8.6
5o	10.04 ± 1.10	48.62 ± 3.58	4.8
5p	16.57 ± 1.32	43.72 ± 3.76	2.6
5q	7.35 ± 0.69	40.36 ± 3.61	5.5
5r	15.77 ± 1.32	45.73 ± 5.43	2.9
5s	11.03 ± 1.45	35.02 ± 3.54	3.2
5t	13.52 ± 1.77	37.97 ± 4.10	2.8
Sorafenib	3.93 ± 0.56	48.36 ± 4.09	12.3

*IC₅₀ values are presented as the mean ± standard deviation (SD) of three independent experiments (n = 3).

**The Selectivity Index (SI) was calculated as the ratio of the IC₅₀ value in HUVEC cells to that in SH-SY5Y cells (SI = IC₅₀ HUVEC / IC₅₀ SH-SY5Y); higher SI values indicate greater selectivity toward cancer cells over normal cells.