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. 2003 Jun;4(6):575–580. doi: 10.1038/sj.embor.embor861

Figure 4.

Figure 4

Expression of catalytically inactive TIP60 delays MYC-dependent H4 acetylation. MYC−/− cells were stimulated with serum and infected with a MYC-expressing adenovirus (AdMyc) in combination with viruses that express either green fluorescent protein (AdGFP), wild-type TIP60 (AdTIP60wt) or catalytically inactive TIP60 (AdTIP60mut). Chromatin immunopreciptiation analysis was performed at the indicated timepoints, using antibodies against acetylated H4 (AcH4; upper panel) or MYC (lower panel). PCR amplification was performed on the same sites as for Fig. 2A.