Figure 2.
Hierarchical clustering of genes that are positively regulated by thyroid hormone in thyroid-hormone-deprived and thyroid-hormone-treated wild-type and knockout mice. Samples are clustered and are presented in the same order as in Fig. 1. Expression ratios are colour-coded according to the scale at the bottom of the figure. Clusters of interest are numbered and are indicated by the black bars on the right. The conditions used are indicated by the colour coding at the top of each column as follows: turquoise, untreated; brown, treated with propylthiouracil (PTU); yellow, treated with 3,3′,5-triiodo-thyronine (T3) and PTU; purple, treated with T3 only. Genotypes are indicated above the colour codes. D, double knockout of the thyroid hormone receptor (Tr) genes Thra and Thrb; KO, knockout; WT, wild type.