Figure 4.

Comparison of T₃-regulated gene expression in wild-type and Thrb knockout mice. The magnitudes of changes in gene expression in response to thyroid hormone (Th) in Th-deprived (propylthiouracil-treated) mice are usually greater in wild-type mice than in mice in which the Thrb gene is knocked out. Individual genes are arranged along the x axis according to the ranked order of decreases and increases in gene expression in wild-type mice. The y axis shows the log ratio of the transcription signals in T₃-treated and euthyroid mice (T₃/euthyroid). KO, knockout; T₃, 3,3′,5-triiodothyronine; Thrb, thyroid-hormone-receptor-β.