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. 2005 Dec 22;116(1):59–69. doi: 10.1172/JCI25074

Figure 3.

Figure 3

Macrophage overexpression of MMP-9 does not alter lesion matrix composition. Representative shoulder regions from lesions from apoE–/– mice transplanted with HSCs transduced with CD68S-HA-EGFP (A–D) or CD68S–MMP-9 (E–H) retroviruses showed similar macrophage content as assessed by staining with an antibody recognizing MAC-2 (A and E) but significant overexpression of MMP-9 in the group receiving CD68S–MMP-9–transduced HSCs (B and F). Collagen content, as measured by staining with Sirius red, was similar in lesions from both groups of mice (C and G), and Verhoeff–Van Gieson (VVG) staining revealed no differences in intimal elastin content or the integrity of the elastin lamelli in the medial arterial wall (D and H). Original magnification, ×20 (A–H).