Figure 9. Absence of RIP140 protects against age- and diet-induced glucose intolerance and enhances insulin responsiveness on a high-fat diet.

Glucose tolerance tests were performed on 3-month-old female mice fed a normal chow diet (A), 8-month-old female mice fed a normal chow diet (B), or 3-month-old female mice fed a high-fat diet (C) for 10 weeks. Values are mean ± SEM; n = 6–12. (D) Insulin tolerance tests were performed on 3-month-old female mice fed a high-fat diet for 9 weeks. Values are mean ± SEM; n = 9.