Figure 4.

Plasma proteome–based biological clocks capture accelerated aging in SCD. (A) The difference between the predicted biological age calculated with the plasma proteome and chronological age (y-axis, DeltaAge) is larger in GEN-MOD patients with SCD than in individuals without SCD from the same cohort. We calculated P values using the Wilcoxon test. (B) A heat map that summarizes the association between DeltaAge from the conventional or organ-specific models and baseline clinical variables. (∗nominal P < .05; ∗∗FDR < 0.05; ∗∗∗Bonferroni-corrected P < .05; correction applied separately for each model). denseRBC, dense RBC; HCT, hematocrit; HGB, hemoglobin; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; PLT, platelet; Retic, reticulocyte.