Figure 13.

Examples of ICTAs treating a disease by suppressing inflammation in RA, DM, AS and AD. (A) MEX + cP ameliorate CIA. (i) Design and preparation of MEX + cP. (ii) The spatial distribution of M1-like macrophages. Reprinted with the permission from Ref. 273. Copyright©2023, John Wiley and Sons. (B) MiR-1249-3p relieves insulin resistance and inflammation. (i) NK-derived exosomal miR-1249-3p regulates insulin resistance in type 2 diabetes mice. (ii) The expression of SKOR1 protein in 3T3-L1 adipocytes. Reprinted with the permission from Ref. 274. Copyright©2021, Springer Nature. (C) Schematic diagram of the MLP-NVs preparation process. Reprinted with the permission from Ref. 235. Copyright©2022, John Wiley and Sons. (D) OT-Lipo@M and its anti-AD mechanisms. Reprinted with the permission from Ref. 275. Copyright©2023, Elsevier.