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. 1979 Jan;43(1):39–43.

Brain viral persistence and myelin damage in nude mice.

M Chew-Lim
PMCID: PMC1319936  PMID: 427638

Abstract

Multiple foci of secondary demyelination were observed in the cerebellum of nude mice given two inoculations of avirulent Semliki Forest virus compared to single lesions seen in similarly treated Swiss A2G mice. The increased number of demyelinative plaques were attributed to brain viral persistence for 35 days in the nude mice with correspondingly low serum antibody titres. No neurological signs were observed in any of the mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adachi M., Volk B. W., Amsterdam D., Brooks S., Tanapat P., Broome J. D. Light and electron microscopic studies of "nude" mice CNS after subcutaneous administration of the E variant of the encephalomyocarditis (EMC) virus. Acta Neuropathol. 1977 Feb 28;37(2):89–93. doi: 10.1007/BF00692053. [DOI] [PubMed] [Google Scholar]
  2. BRADISH C. J., FARLEY J. O., FERRIER H. E. Studies on the nature of the nature of the neutralization reaction and the competition for neutralizing antibody between components of the virus system of foot-and-mouth disease. Virology. 1962 Nov;18:378–400. doi: 10.1016/0042-6822(62)90029-6. [DOI] [PubMed] [Google Scholar]
  3. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci. J Exp Med. 1971 May 1;133(5):1090–1104. doi: 10.1084/jem.133.5.1090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. J Exp Med. 1970 Nov;132(5):1035–1054. doi: 10.1084/jem.132.5.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J Exp Med. 1971 May 1;133(5):1074–1089. doi: 10.1084/jem.133.5.1074. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Blanden R. V. T cell response to viral and bacterial infection. Transplant Rev. 1974;19(0):56–88. doi: 10.1111/j.1600-065x.1974.tb00128.x. [DOI] [PubMed] [Google Scholar]
  7. Bradish C. J., Allner K., Maber H. B. The virulence of original and derived strains of Semliki forest virus for mice, guinea-pigs and rabbits. J Gen Virol. 1971 Aug;12(2):141–160. doi: 10.1099/0022-1317-12-2-141. [DOI] [PubMed] [Google Scholar]
  8. Chew-Lim M., Scott T., Webb H. E. An ultrastructure study of cerebellar lesions induced in mice by three inoculations of avirulent Semliki forest virus. Acta Neuropathol. 1978 Jan 19;41(1):55–59. doi: 10.1007/BF00689557. [DOI] [PubMed] [Google Scholar]
  9. Chew-Lim M., Suckling A. J., Webb H. E. Demyelination in mice after two or three infections with avirulent Semliki Forest virus. Vet Pathol. 1977 Jan;14(1):62–72. doi: 10.1177/030098587701400108. [DOI] [PubMed] [Google Scholar]
  10. Chew-Lim M., Webb H. E., Jagelman S. The effect of irradiation on demyelination induced by avirulent Semliki Forest virus. Br J Exp Pathol. 1977 Oct;58(5):459–464. [PMC free article] [PubMed] [Google Scholar]
  11. Clarke G. L., Osburn B. I. Transmissible congenital demyelinating encephalopathy of lambs. Vet Pathol. 1978 Jan;15(1):68–82. doi: 10.1177/030098587801500109. [DOI] [PubMed] [Google Scholar]
  12. Doherty P. C., Zinkernagel R. M., Ramshaw I. A. Specificity and development of cytotoxic thymus-derived lymphocytes in lymphocytic choriomeningitis. J Immunol. 1974 Apr;112(4):1548–1552. [PubMed] [Google Scholar]
  13. Fitzgeorge R. B., Bradish C. J. Immunospecific isolation of antibodies by dissociation from virus or particulate antigen adsorbed on charcoal. Immunochemistry. 1973 Jan;10(1):21–29. doi: 10.1016/0019-2791(73)90246-2. [DOI] [PubMed] [Google Scholar]
  14. Fleming P. Age-dependent and strain-related differences of virulence of Semliki Forest virus in mice. J Gen Virol. 1977 Oct;37(1):93–105. doi: 10.1099/0022-1317-37-1-93. [DOI] [PubMed] [Google Scholar]
  15. Fraser K. B. Multiple sclerosis: a virus disease? Br Med Bull. 1977 Jan;33(1):34–39. doi: 10.1093/oxfordjournals.bmb.a071392. [DOI] [PubMed] [Google Scholar]
  16. Freedman L. R., Cerottini J. C., Brunner K. T. In vivo studies of the role of cytotoxic T cells in tumor allograft immunity. J Immunol. 1972 Dec;109(6):1371–1378. [PubMed] [Google Scholar]
  17. KLUVER H., BARRERA E. A method for the combined staining of cells and fibers in the nervous system. J Neuropathol Exp Neurol. 1953 Oct;12(4):400–403. doi: 10.1097/00005072-195312040-00008. [DOI] [PubMed] [Google Scholar]
  18. Kaplan M. M., Wiktor T. J., Koprowski H. Pathogenesis of rabies in immunodeficient mice. J Immunol. 1975 Jun;114(6):1761–1765. [PubMed] [Google Scholar]
  19. Leclerc J. C., Gomard E., Plata F., Levy J. P. Cell-mediated immune reaction against tumors induced by oncornaviruses. II. Nature of the effector cells in tumor-cell cytolysis. Int J Cancer. 1973 Mar 15;11(2):426–432. doi: 10.1002/ijc.2910110220. [DOI] [PubMed] [Google Scholar]
  20. Parker J. C., Jr, Klintworth G. K., Graham D. G., Griffith J. F. Uncommon morphologic features in subacute sclerosing panencephalitis (SSPE). Report of two cases with virus recovery from one autopsy brain specimen. Am J Pathol. 1970 Nov;61(2):275–292. [PMC free article] [PubMed] [Google Scholar]
  21. Tellez-Nagel I., Harter D. H. Subacute sclerosing leukoencephalitis. I. Clinico-pathological, electron microscopic and virological observations. J Neuropathol Exp Neurol. 1966 Oct;25(4):560–581. doi: 10.1097/00005072-196610000-00005. [DOI] [PubMed] [Google Scholar]
  22. Wiśniewski H. M. Immunopathology of demyelination in autoimmune diseases and virus infections. Br Med Bull. 1977 Jan;33(1):54–59. doi: 10.1093/oxfordjournals.bmb.a071397. [DOI] [PubMed] [Google Scholar]
  23. Wiśniewski H., Raine C. S., Kay W. J. Observations on viral demyelinating encephalomyelitis. Canine distemper. Lab Invest. 1972 May;26(5):589–599. [PubMed] [Google Scholar]
  24. Wortis H. H. Immunological responses of 'nude' mice. Clin Exp Immunol. 1971 Feb;8(2):305–317. [PMC free article] [PubMed] [Google Scholar]
  25. Zinkernagel R. M., Althage A. Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled. J Exp Med. 1977 Mar 1;145(3):644–651. doi: 10.1084/jem.145.3.644. [DOI] [PMC free article] [PubMed] [Google Scholar]

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