Table 3.
Survival analysis of hsa-let-7b-5p-associated positive genes
| S. No. | Associated genes | Survival | Patient No. | p-value | HR | CI | Low expression cohort (months) | High expression cohort (months) |
|---|---|---|---|---|---|---|---|---|
| OS/FP/PPS | ||||||||
| 1 | CPED1 | OS | 1411 | 2.3e-13 | 0.58 | 0.5–0.67 | 51 | 107 |
| FP | 874 | 0.00048 | 0.68 | 0.55–0.84 | 14 | 33.23 | ||
| PPS | 242 | 0.00027 | 0.58 | 0.43–0.78 | 8 | 16.07 | ||
| 2 | EFCAB14 | OS | NA | |||||
| FP | ||||||||
| PPS | ||||||||
| 3 | COLEC12 | OS | 2166 | 1.3e-08 | 0.71 | 0.63–0.8 | 52 | 84 |
| FP | 1252 | 0.00015 | 0.72 | 0.61-0.085.61.085 | 70 | 104.9 | ||
| PPS | 477 | 0.0014 | 0.71 | 0.58–0.88 | 9 | 19 | ||
| 4 | DLC1 | OS | 2166 | 1e-09 | 1.45 | 1.29–1.64 | 86 | 52 |
| FP | 1252 | 0.034 | 1.2 | 1.01–1.42 | 102 | 81 | ||
| PPS | 477 | 0.00019 | 1.49 | 1.2–1.83 | 20 | 9 | ||
| 5 | SEPT4 | OS | 2166 | 0.069 | 0.9 | 0.8–1.01 | 65 | 72.33 |
| FP | 1252 | 0.088 | 0.86 | 0.73–1.02 | 88 | 104 | ||
| PPS | 477 | 0.58 | 1.06 | 0.86–1.31 | 13.57 | 13.2 | ||
| 6 | TGFBR3 | OS | 2166 | 1.4e-08 | 0.71 | 0.63–0.8 | 53 | 85 |
| FP | 1252 | 1.2e-08 | 0.61 | 0.52–0.73 | 50 | 164 | ||
| PPS | 477 | 0.00078 | 0.7 | 0.57–0.86 | 10 | 20 | ||
| 7 | RNF144B | OS | 1411 | 1.5e-09 | 0.63 | 0.55–0.74 | 52 | 91 |
| FP | 874 | 1.1e-06 | 0.58 | 0.47–0.73 | 14 | 34.9 | ||
| PPS | 242 | 0.0097 | 0.68 | 0.5–0.91 | 8.98 | 15 | ||
| 8 | CD59 | OS | 1411 | 9.1e-08 | 0.67 | 0.58–0.78 | 52 | 96.2 |
| FP | 874 | 7.9e-06 | 0.61 | 0.49–0.76 | 14.43 | 35 | ||
| PPS | 242 | 8.9e-05 | 0.56 | 0.41–0.75 | 8 | 20 | ||
| 9 | MAT2B | OS | 2166 | 4.9e-07 | 0.74 | 0.66–0.83 | 57 | 81 |
| FP | 1252 | 3.6e-05 | 0.7 | 0.59–0.83 | 12 | 22.53 | ||
| PPS | 477 | 0.0054 | 0.75 | 0.61–0.92 | 10.38 | 17.67 | ||
| 10 | CHMP3 | OS | 2166 | 9.4e-07 | 0.74 | 0.66–0.84 | 56 | 84 |
| FP | 1252 | 1.5e-10 | 0.58 | 0.48–0.68 | 11 | 26.33 | ||
| PPS | 477 | 0.2 | 0.87 | 0.71–1.08 | 11.4 | 15 | ||
| OS/FP/PPS+LUAD | ||||||||
| 1 | CPED1 | OS+ LUAD | 672 | 8e-12 | 0.42 | 0.32–0.54 | 69 | 175 |
| FP+ LUAD | 528 | 0.0012 | 0.61 | 0.45–0.83 | 21 | 43.07 | ||
| PPS+ LUAD | 141 | 0.0054 | 0.55 | 0.36–0.84 | 11 | 22 | ||
| 2 | COLEC12 | OS+ LUAD | 1161 | 7.8e-07 | 0.65 | 0.54–0.77 | 62 | 96.2 |
| FP + LUAD | 906 | 1.6e-06 | 0.61 | 0.5–0.75 | 50 | 164 | ||
| PPS+ LUAD | 376 | 0.13 | 0.83 | 0.65–1.05 | 13.57 | 20 | ||
| 3 | TGFBR3 | OS+ LUAD | 672 | 3.9e-10 | 0.45 | 0.35–0.58 | 66.47 | 175 |
| FP+ LUAD | 528 | 1.6e-05 | 0.52 | 0.38–0.7 | 19 | 48.73 | ||
| PPS+ LUAD | 141 | 0.0061 | 0.56 | 0.36–0.85 | 10.81 | 24.47 | ||
| 4 | RNF144B | OS+ LUAD | 672 | 1.4e-06 | 0.54 | 0.42–0.7 | 24.33 | 49.4 |
| FP+ LUAD | 528 | 0.014 | 0.69 | 0.51–0.93 | 25 | 41.4 | ||
| PPS+ LUAD | 141 | 0.00043 | 0.47 | 0.31–0.72 | 11 | 27.07 | ||
| 5 | CD59 | OS+ LUAD | 672 | 6.8e-09 | 0.48 | 0.38–0.62 | 69 | 133.57 |
| FP+ LUAD | 528 | 0.0022 | 0.63 | 0.46–0.85 | 21.3 | 42.7 | ||
| PPS+ LUAD | 141 | 0.00014 | 0.44 | 0.29–0.68 | 10.38 | 27.07 | ||
| 6 | MAT2B | OS+ LUAD | 1161 | 5.1e-08 | 0.62 | 0.52–0.74 | 64 | 107 |
| FP+ LUAD | 906 | 1.9e-06 | 0.62 | 0.5–0.75 | 13 | 26.33 | ||
| PPS+ LUAD | 376 | 0.038 | 0.78 | 0.61–0.99 | 13 | 21 | ||
| OS+LUAD+SMOKERS | ||||||||
| 1 | CPED1 | OS+LUAD+ SMOKERS | 231 | 0.0041 | 0.48 | 0.29–0.8 | - | - |
| 2 | TGFBR3 | OS+LUAD+ SMOKERS | 231 | 0.00045 | 0.41 | 0.24–0.68 | - | - |
| 3 | RNF144B | OS+LUAD+ SMOKERS | 231 | 0.0046 | 0.49 | 0.3–0.81 | - | - |
| 4 | CD59 | OS+LUAD+ SMOKERS | 231 | 0.0017 | 0.45 | 0.27–0.75 | 35 | 68 |
| 5 | MAT2B | OS+LUAD+ SMOKERS | 231 | 0.1 | 0.8 | 0.62–1.04 | 71 | 93 |