Table 4.
Survival analysis of hsa-let-7b-5p-associated negative genes
| S.No. | Associated genes | Survival | Patient No. | p-value | HR | CI | Low expression cohort (months) |
High expression cohort (months) |
|---|---|---|---|---|---|---|---|---|
| OS/FP/PPS | ||||||||
| 1 | ESPL1 | OS | 2166 | 5.9e-10 | 1.45 | 1.29–1.64 | 86.27 | 51 |
| FP | 1252 | 5.5e-15 | 1.97 | 1.65–2.34 | 29 | 10.5 | ||
| PPS | 477 | 0.08 | 1.2 | 0.98–1.48 | 16.07 | 10.78 | ||
| 2 | AURKB | OS | 2166 | < 1e-16 | 1.78 | 1.58–2.01 | 93 | 43.83 |
| FP | 1252 | 8.3e-13 | 1.85 | 1.56–2.2 | 31.61 | 10 | ||
| PPS | 477 | 8.3e-06 | 1.6 | 1.3–1.98 | 21.9 | 9 | ||
| 3 | CCNF | OS | 2166 | 2.5e-06 | 1.33 | 1.18–1.5 | 85 | 55 |
| FP | 1252 | 2.5e-07 | 1.56 | 1.32–1.85 | 23 | 12 | ||
| PPS | 477 | 0.57 | 1.06 | 0.86–1.31 | 15.01 | 12 | ||
| 4 | EZH2 | OS | 2166 | 1.3e-05 | 1.3 | 1.16–1.47 | 81 | 54 |
| FP | 1252 | 5.6e-06 | 1.48 | 1.25–1.75 | 25 | 12 | ||
| PPS | 477 | 0.17 | 1.15 | 0.94–1.42 | 17.25 | 10.81 | ||
| 5 | PLK1 | OS | 2166 | < 1e-16 | 1.68 | 1.49–1.9 | 91 | 48 |
| FP | 1252 | < 1e-16 | 2.28 | 1.92–2.72 | 36 | 10 | ||
| PPS | 477 | 0.072 | 1.21 | 0.98–1.49 | 18 | 11 | ||
| 6 | E2F2 | OS | 1411 | 1.2e-10 | 1.62 | 1.4–1.89 | 103 | 51 |
| FP | 874 | 1.2e-06 | 1.72 | 1.38–2.14 | 34.9 | 15 | ||
| PPS | 242 | 0.0079 | 1.49 | 1.11–2.11 | 15.7 | 9 | ||
| 7 | PUS1 | OS | 2166 | 0.32 | 0.94 | 0.84–1.06 | 68 | 72.33 |
| FP | 1252 | 0.23 | 0.9 | 0.76–1.07 | 79 | 104 | ||
| PPS | 477 | 0.77 | 0.97 | 0.79–1.19 | 15 | 12 | ||
| 8 | AURKA | OS | 2166 | 2.3e-11 | 1.5 | 1.33–1.69 | 93 | 49.47 |
| FP | 1252 | 1.1e-08 | 1.64 | 1.38–1.94 | 27 | 11 | ||
| PPS | 477 | 0.01 | 1.31 | 1.07–1.62 | 19.47 | 10.81 | ||
| 9 | KIFC1 | OS | 2166 | < 1e-16 | 1.72 | 1.52–1.94 | 96 | 45 |
| FP | 1252 | 2.3e-14 | 1.94 | 1.63–2.3 | 30 | 10.3 | ||
| PPS | 477 | 0.00032 | 1.47 | 1.19–1.81 | 20.11 | 9.26 | ||
| 10 | HASPIN | OS | 1411 | 2.5e-09 | 1.56 | 1.35–1.81 | 95.07 | 52 |
| FP | 874 | 8.1e-10 | 1.98 | 1.58–2.47 | 43 | 13 | ||
| PPS | 242 | 0.014 | 1.44 | 1.08–1.94 | 15.7 | 9.26 | ||
| OS/FP/PPS + LUAD | ||||||||
| 1 | AURKB | OS+ LUAD | 1161 | < 1e-16 | 2.11 | 1.77–2.52 | 117.33 | 49.43 |
| FP+ LUAD | 906 | 9e-14 | 2.14 | 1.74–2.63 | 35 | 11 | ||
| PPS+ LUAD | 376 | 5e-04 | 1.53 | 1.2–1.95 | 24.4 | 11 | ||
| 2 | E2F2 | OS+ LUAD | 672 | 2e-10 | 2.2 | 1.72–2.83 | 133.57 | 63.4 |
| FP+ LUAD | 528 | 0.00015 | 1.78 | 1.31–2.4 | 48.73 | 22 | ||
| PPS+ LUAD | 141 | 0.28 | 1.26 | 0.83–1.92 | 21 | 12 | ||
| 3 | AURKA | OS/LUAD | 1161 | 4.2e-07 | 1.56 | 1.31–1.85 | 106 | 63.4 |
| FP/LUAD | 906 | 4.2e-09 | 1.82 | 1.48–2.22 | 32 | 12 | ||
| PPS/LUAD | 376 | 0.087 | 1.23 | 0.97–1.57 | 21.9 | 12 | ||
| 4 | KIFC1 | OS/LUAD | 1161 | 1.6e-13 | 1.91 | 1.61–2.28 | 114 | 52 |
| FP/LUAD | 906 | 6.6e-14 | 2.15 | 1.75–2.64 | 33.23 | 11 | ||
| PPS/LUAD | 376 | 0.0033 | 1.43 | 1.13–1.83 | 22 | 11 | ||
| 5 |
HASPIN (Gsg2) |
OS/LUAD | 672 | 0.014 | 1.35 | 1.06–1.71 | 117.33 | 86 |
| FP/LUAD | 528 | 0.027 | 1.4 | 1.04–1.88 | 38.13 | 22 | ||
| PPS/LUAD | 141 | 0.35 | 1.22 | 0.8–1.86 | 21 | 13.57 | ||
| OS+LUAD+SMOKERS | ||||||||
| 1 | AURKB | OS+LUAD+ SMOKERS | 546 | 3.3e-08 | 2.1 | 1.61–2.75 | 116 | 57 |
| 2 | KIFC1 | OS+LUAD+ SMOKERS | 546 | 1.7e-06 | 1.9 | 1.45–2.47 | 114 | 57 |