Table 2.
Substantia Nigra (SN) and Dentate Nucleus (DN) Lewy pathology in iPD and age-matched control brains (HE assessment).
| Lewy pathology (LB, LN) in SN and DN | Neuronal loss | Neuromelanin pigment incontinence | HE-detectable intraneuronal inclusions (LB, LN, other) | Vascular pathology | |||||
|---|---|---|---|---|---|---|---|---|---|
| Microhemorrhages | |||||||||
| Subject# | SN | DN | SN | DN | SN | SN | DN | SN | DN |
| #1 (iPD) | Yes | Yes | Mild | No | Moderate | Yes | Yes | No | No |
| #2 (iPD) | Yes | Yes | Severe | No | Moderate | Yes | Yes | No | No |
| #3 (iPD) | Yes | Yes | Severe | No | Mild | Yes | Yes | No | No |
| #4 (iPD) | Yes | Yes | Moderate | No | Mild | Yes | Yes | No | No |
| #5 (iPD) | Yes | Yes | Mild | No | Mild | Yes | Yes | No | No |
| #6 (iPD) | Yes | Yes | Moderate | No | Mild | Yes | Yes | No | No |
| #7 (C) | No | No | Neg | Neg | Neg | Neg | Neg | No | No |
| #8 (C) | No | No | Neg | Neg | Neg | Neg | Neg | No | No |
| #9 (C) | No | No | Neg | Neg | Neg | Neg | Neg | No | No |
| #10 (C) | No | No | Neg | Neg | Neg | Neg | Neg | No | No |
| #11 (C) | No | No | Neg | Neg | Neg | Neg | Neg | No | No |
This table details the neuropathological findings obtained via Hematoxylin and Eosin (HE) assessment for the study cohort. Observations for iPD subjects (#1–6) and controls (#7–11) include the presence of Lewy pathology (Lewy bodies and Lewy neurites), the severity of neuronal loss, and the presence of neuromelanin pigment incontinence1.The table also documents the presence of HE-detectable intraneuronal inclusions and vascular pathology, specifically microhemorrhages. SN, Substantia Nigra; DN, Dentate Nucleus; LB, Lewy Body; LN, Lewy Neurite; HE, Hematoxylin and Eosin; Neg, Negative.