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. 2026 Apr 4;16:16233. doi: 10.1038/s41598-026-46997-7

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Influence of Nintedanib and Regorafenib on the Akt/mTOR-signaling pathway in CRC cells. HT-29 and LoVo cells were exposed to the IC₅₀ dose of Nintedanib and Regorafenib for the indicated times, and the expression of proteins involved in the Erk/RSK pathway were determined by Western blot analysis. The protein levels of β-actin are shown as the loading control. The numbers reflect the expression of the indicated protein in drug-exposed cells compared to the corresponding untreated control. Representative Western blots from one out of at least 2 experiments.