Table 4.

Meta-analysis results of adverse events

Outcome	Meta-analysis		Heterogeneity		Certainty
	Risk ratio (95% CI)	p-value	τ 2	Prediction interval
Abdominal pain	2.93 (1.13–7.6)	0.027	0	1.13–7.60	High
Constipation	3.23 (1.14–9.18)	0.028	0.38	0.65–16.03	Moderate
Diarrhoea	1.5 (0.69–3.24)	0.308	0.14	0.52–4.34	Low
Nausea	1.44 (0.87–2.39)	0.152	0.08	0.69–3.02	Low
Serious adverse event	0.81 (0.52–1.26)	0.345	0	0.52–1.26	Low
Vomiting	2.57 (1.39–4.77)	0.003	0	1.39–4.77	High