3D TCSs	3D tumor cell spheroids
AUC	Area under the curve
DEGs	Differential expressed genes
GO	Gene ontology
GSH	Glutathione
HCC	Hepatocellular carcinoma
IL-6	Interleukin-6
KEGG	Kyoto encyclopedia of genes and genomes
LDH	lactate dehydrogenase
MALDI MSI	matrix-assisted laser desorption/ionization mass spectrometry imaging
MRI	Magnetic resonance imaging
NLRP3	NOD-like receptor protein 3
OFR	Oxygen free radical
pLSA	Probabilistic latent semantic analysis
SOR	Sorafenib
TME	Tumor microenvironment
TNF-α	Tumor necrosis factor-α