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. 2026 May 21;27(10):4640. doi: 10.3390/ijms27104640
T2DM Type 2 diabetes mellitus
pVHL Von Hippel–Lindau protein
HIF-1α Hypoxia-inducible factor 1-alpha
VEGF Vascular endothelial growth factor
HCD High-calorie diet
SD Standard diet
MFI Mean fluorescence intensity
AdVHL Adenoviral vector encoding the murine Vhlh gene
AdGFP Adenoviral vector encoding the GFP gene
PBS Phosphate-buffered saline
IHC Immunohistochemistry
IF Immunofluorescence
UPR Unfolded protein response
ER Endoplasmic reticulum
niAUC Net incremental area under the curve