Skip to main content
. 2026 May 21;27(10):4621. doi: 10.3390/ijms27104621
BPSD Behavioral and psychological symptoms of dementia
AD Alzheimer’s disease
MCI mild cognitive impairment
Aβ amyloid-beta
ADNC Alzheimer’s disease neuropathologic change
MBI Mild Behavioral Impairment
HR Hazard Ratios
MTHFR methylenetetrahydrofolate reductase
DAM disease-associated microglia
CSF cerebrospinal fluid
sTREM2 soluble TREM2
LDAM lipid-droplet-accumulating microglia
NPS neuropsychiatric symptoms
WMH white matter hyperintensities
OR odds ratio
CNS Central Nervous System
AβOs amyloid-β oligomers
TLR4 Toll-like receptor 4
5-HT serotonin
IL-1ra IL-1 receptor antagonist
GDNF glial cell line-derived neurotrophic factor
LCN2 lipocalin-2
TBARS Thiobarbituric Acid Reactive Substances
ACC Anterior Cingulate Cortex
ChEIs acetylcholinesterase inhibitors
α7nAChRs α7 nicotinic acetylcholine receptors
SERT serotonin transporter
IDO indoleamine-2,3-dioxygenase
DRD2 dopamine D2 receptor
CRYAB αB-crystallin
mGluR5 metabotropic glutamate receptor 5
CIH chronic intermittent hypoxia
LRP Lewy-related pathology
HMGB1 high-mobility group box 1
UCP4 uncoupling protein 4
eNMDARs extrasynaptic NMDA receptors
COPD Chronic Obstructive Pulmonary Disease
OPCs oligodendrocyte progenitor cells
βHB β-hydroxybutyrate
NPI Neuropsychiatric Inventory
DAMPs damage-associated molecular patterns
CAT catalase
SSRIs selective serotonin reuptake inhibitors
iPSCs induced pluripotent stem cells
GRP Glial-restricted precursor
CBD Cannabidiol
MADRS Montgomery–Åsberg Depression Rating Scale
HAM-A Hamilton Anxiety Rating Scale