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. 2026 May 13;15(10):3742. doi: 10.3390/jcm15103742
ACM Arrhythmogenic cardiomyopathy
ADAM A Disintegrin and Metalloproteinase
ADAMTS Disintegrin and Metalloproteinase with Thrombospondin Motifs
AF Atrial fibrillation
AI Artificial intelligence
α-SMA Alpha-smooth muscle actin
ASCOT Anglo-Scandinavian Cardiac Outcomes Trial
BNP B-type natriuretic peptide
CAD Coronary artery disease
CD44 Cluster of differentiation 44
CHD Coronary heart disease
CITP Carboxy-terminal telopeptide of type I collagen
CKD Chronic kidney disease
CMR Cardiac magnetic resonance
CVF Collagen volume fraction
DAMPs Damage-associated molecular patterns
DCM Dilated cardiomyopathy
DE-CMR Delayed-enhancement cardiac magnetic resonance
DECAAF Delayed-Enhancement MRI Determinant of Successful Radiofrequency Catheter Ablation of Atrial Fibrillation
ECM Extracellular matrix
ECV Extracellular volume
E/e′ Ratio of early mitral inflow velocity to early diastolic mitral annular velocity
eGFR Estimated glomerular filtration rate
ELISA Enzyme-linked immunosorbent assay
EMPEROR Empagliflozin Outcome Trial in Patients with Chronic Heart Failure
EndMT Endothelial-to-mesenchymal transition
ERK1/2 Extracellular signal-regulated kinase 1/2
FDA Food and Drug Administration
Gal-3 Galectin-3
HCM Hypertrophic cardiomyopathy
HF Heart failure
HFmrEF Heart failure with mildly reduced ejection fraction
HFpEF Heart failure with preserved ejection fraction
HFrEF Heart failure with reduced ejection fraction
HIV Human immunodeficiency virus
HOMAGE Heart Omics in AGEing
IL-33 Interleukin-33
JNK1/2 c-Jun N-terminal kinase 1/2
LA Left atrial
LGE Late gadolinium enhancement
LV Left ventricular
MAPK Mitogen-activated protein kinase
MF Myocardial fibrosis
MI Myocardial infarction
MMP Matrix metalloproteinase
MMP-1 Matrix metalloproteinase-1
MMP-9 Matrix metalloproteinase-9
MMP-12 Matrix metalloproteinase-12
MVP Mitral valve prolapse
NT-proBNP N-terminal pro-B-type natriuretic peptide
PAH Pulmonary arterial hypertension
MeSH Medical Subject Headings
PICP C-terminal propeptide of procollagen type I
PI3K/Akt Phosphoinositide 3-kinase/Protein kinase B signaling pathway
PINP N-terminal propeptide of procollagen type I
PIIINP N-terminal propeptide of procollagen type III
PIP Procollagen type I C-terminal propeptide
RAAS Renin–angiotensin–aldosterone system
RCT Randomized controlled trial
ROCKs Rho-associated coiled-coil-containing protein kinases
ROS Reactive oxygen species
SGLT2 Sodium–glucose cotransporter 2
SIV Simian immunodeficiency virus
SMAD Intracellular signaling proteins mediating TGF-β signaling
sST2 Soluble suppression of tumorigenicity 2
SPP1 Secreted phosphoprotein 1
TAC Transverse aortic constriction
TGF-β Transforming growth factor beta
TIMP Tissue inhibitor of metalloproteinases
TIMP-1 Tissue inhibitor of metalloproteinases 1
TIMP-3 Tissue inhibitor of metalloproteinases 3
TIMP-4 Tissue inhibitor of metalloproteinases 4
VEGF Vascular endothelial growth factor