TABLE 2 ∣.
Simulation results for the proposed trial design.
| Case | Scenario | Average sample size | Percentage of early termination |
|---|---|---|---|
| 1 | No treat effect No marker effect |
316.2 | 0.85 |
| 2 | Constant treat effect No marker effect |
156.1 | 1.00 |
| 3 | Prognostic marker effect No treat effect |
310.4 | 0.83 |
| 4 | Predictive marker effect (perfectly dichotomous) |
410.4 | 0.71 |
| 5 | Predictive marker effect (nearly dichotomous) |
426.5 | 0.60 |
| 6 | Predictive marker effect (linear) |
424.4 | 0.56 |
| 7 | Predictive marker effect (non-linear and monotone) |
293.5 | 0.88 |
| 8 | Predictive marker effect (non-linear and monotone) |
436.0 | 0.51 |
| 9 | Predictive marker effect (non-linear and non-monotone) |
446.6 | 0.49 |
| 10 | Predictive marker effect (non-linear and non-monotone) |
447.2 | 0.50 |
| 11 | Constant inferior treat effect (No marker effect) |
114.5 | 1.00 |
| 12 | Prognostic and predictive marker effect (linear; nearly dichotomous) |
416.3 | 0.62 |