Table 1.
Comparison of alginate products and their raft and acid-neutralizing characteristics
| Product | Alginate | Antacid(s) | ANC | Raft characteristics | ||
|---|---|---|---|---|---|---|
| acid trapping | duration of simulated reflux neutralization | alginate content* within the raft at pH 1.0 | ||||
| | mg/max dose | mg/max dose | mEq/dose | yes/no | minutes | mg |
| GDA | Sodium alginate 1000 | Calcium carbonate 650 | 7.9 | Yes (absorbent) | 93 | 550 |
| Sodium bicarbonate 426 | ||||||
| GO | Sodium alginate 1000 | Sodium bicarbonate 534 | 3.6 | Yes (absorbent) | 61 | 515 |
| Calcium carbonate 320 | ||||||
| Peptac | Sodium alginate 1000 | Sodium bicarbonate 534 | 3.3 | No (nonabsorbent) | 16 | 205 |
| Calcium carbonate 320 | ||||||
| Algycon | Alginic acid 600 | Aluminum hydroxide 90 | 1.3 | No (no structure) | 0 | 215 |
| Magnesium carbonate 120 | ||||||
| Maalox | Sodium alginate 500 | Calcium carbonate 164 | 1.7 | No (nonabsorbent) | 21 | 175 |
| Mylan | Sodium alginate 1000 | Sodium bicarbonate 534 | 2.2 | No (nonabsorbent) | 5 | 235 |
| Rennie Duo | Sodium alginate 300 | Calcium carbonate 1200 | 12.8 | No (highly porous) | 27 | 185 |
| Magnesium carbonate 140 | ||||||
Table adapted from Dettmar et al. [50].
ANC, acid-neutralizing capacity; AUC, area under the curve; GDA, Gaviscon Double Action; GO, Gaviscon Original.
*Estimates derived from plotted data [50]. GDA and GO liquid (Reckitt, Slough, UK), Peptac liquid (Pinewood Laboratories Limited, Clonmel, Ireland), Algycon tablets (American Taiwan Biopharma, Bangkok, Thailand), Maalox RefluRAPID (Sanofi-Aventis, Gentilly, France) liquid suspension, Mylan liquid suspension (Mylan, Pennsylvania, USA), and Rennie Duo (Bayer, Leverkusen, Germany) liquid suspension. All measurements relate to the maximum recommended dose of alginate product.