TABLE 2.
Distribution of ABCB1, CYP3A4, and CYP3A5 genotypes according to tacrolimus metabolic phenotypes.
| Gene and polymorphism | High metabolism phenotype | Low metabolism phenotype | p-value |
|---|---|---|---|
| ABCB1 rs1045642, n (%) | | | 0.423 |
| C/C | 10 (25.6) | 5 (13.2) | |
| C/T | 19 (48.7) | 21 (55.3) | |
| T/T | 10 (25.6) | 11 (28.9) | |
| ABCB1 rs1128503, n (%) | | | 0.728 |
| C/C | 17 (43.6) | 18 (47.4) | |
| T/C | 17 (43.6) | 14 (36.8) | |
| T/T | 5 (12.8) | 5 (13.2) | |
| ABCB1 rs2032582, n (%) | | | 0.924 |
| G/G | 20 (51.3) | 19 (50.0) | |
| G/T | 14 (35.9) | 15 (39.5) | |
| T/T | 5 (12.8) | 4 (10.5) | |
| CYP3A4 rs2242480, n (%) | | | 0.054 |
| A/A | 5 (12.8) | 1 (2.6) | |
| G/A | 14 (35.9) | 7 (18.4) | |
| G/G | 20 (51.3) | 29 (76.3) | |
| CYP3A5 rs776746 (*3), n (%) | | | 0.001 |
| A/A | 2 (5.1) | 1 (2.6) | |
| A/G | 17 (43.6) | 3 (7.9) | |
| G/G | 20 (51.3) | 34 (89.5) | |