Table 1.
Brain microarray data for mouse chromosome 7B2-C genesa in TgPWS vs. WT mice.
| GenBank | Affy ID | Gene | mRNA levelb | Chr. 7 location (Mb and/or cM) | |
| TgPWS | WT | ||||
| I. Genes centromeric of the TgPWS/TgAS deletion | |||||
| NM_008087 | 94337_at | Gas2 | 4.3 (3/5) | 5.0 (2/5) | 39.3 Mb; 26.8 cM |
| 94338_g_at | Gas2 | 43.1 (5/5) | 42.92 (5/5) | as above | |
| AK049836 | 97539_at | Hrmt1l3 | 50.2 (5/5) | 44.5 (4/5) | 37.25 Mb |
| NM_016865 | 103671_at | Htatip2 | 23.8 (0/5) | 21.0 (0/5) | 37.2 Mb |
| AY957576 | 103202_f_at | E2F8 | 35.3 (4/5) | 30.4 (4/5) | 36.3 Mb |
| 103204_r_at | E2F8 | 27.4 (1/5) | 21.6 (2/5) | as above | |
| NM_013808 | 103084_at | Csrp3 | 4.6 (0/5) | 3.2 (0/5) | 36.3 Mb |
| NM_013643 | 100406_at | Ptpn5 | 399.8 (5/5) | 406.1 (5/5) | 34.5 Mb |
| NM_016855 | 95304_at | Attp | 8.5 (0/5) | 8.7 (0/5) | 34.3 Mb |
| NM_021884 | 94809_at | Tsg101 | 56.5 (5/5) | 56.6 (5/5) | 34.3 Mb |
| NM_013580 | 93103_at | Ldh3 | 1.7 (0/5) | 1.3 (0/5) | 34.3 Mb; 23.5 cM |
| II. Genes telomeric of the TgPWS/TgAS deletion | |||||
| NM_007390 | 101131_at | Chrna7 | 86.8 (0/5) | 87.1 (0/5) | 50.1 Mb; 30.0 cM |
| NM_021366 | 160617_at | Klf13 | 145.2 (5/5) | 155.6 (5/5) | 50.9 Mb |
| NM_018752 | 102251_at | Trpm1 | 77.7 (1/5) | 56.7 (0/5) | 51.2 Mb; 27.0 cM |
| BC055074 | 93235_at | BB128963 | 51.3 (5/5) | 46.0 (5/5) | 51.3 Mb |
| NM_026483 | 104022_at | Mphosph10 | 35.9 (0/5) | 34.0 (0/5) | 51.4 Mb |
| NM_028626 | 102022_at | Mcee | 79.6 (5/5) | 81.1 (5/5) | 51.4 Mb |
| NM_007461 | 92727_at | Apba2 | 433.9 (5/5) | 455.8 (5/5) | 51.5 Mb; 25.5 cM |
| NM_009386 | 99935_at | Tjp1 | 185.3 (5/5) | 142.5 (5/5) | 52.3 Mb; 28.5 cM |
| D50060 | 101196_at | Pace4 | 78.3 (0/5) | 71.2 (0/5) | 52.9 Mb; 28.5 cM |
| NM_021336 | 101506_at | Snrpa1 | 131.2 (5/5) | 126 (5/5) | 53.1 Mb |
| NM_024439 | 94245_at | H47 | 141.8 (5/5) | 144.2 (5/5) | 53.1 Mb; 28.5 cM |
| NM_053080 | 98372_at | Aldh1a3 | 13.3 (0/5) | 9.8 (0/5) | 53.4 Mb |
| NM_194070 | 93852_at | Mef2a | 399.9 (5/5) | 417.4 (5/5) | 54.3 Mb; 33.0 cM |
| AF056187 | 102224_at | Igf1r | 381.6 (5/5) | 339.6 (5/5) | 55.0 Mb; 33.0 cM |
a The primary microarray data from this experiment were reported in reference 15. As summarized in Fig. 1A, reference 15 included the data for the imprinted genes within the TgPWS/TgAS deletion that are on the MG-U74Av2 chip (Snrpn, Ndn, Magel2, Mkrn3 and Ube3a) and for non-imprinted genes within the deletion (Cyfip1, Herc2, and Gabrb3, although the latter transcript was not detectable; the p gene is also represented on the chip although not detectable in TgPWS or WT mice, and not previously reported). Additionally, a cluster of chromosome 18B3 genes were found to be abnormally expressed in TgPWS mice [15]. b mRNA levels are presented as the medians of Signal (relative abundance of a transcript), for TgPWS (n = 5) and WT (n = 5), with the number of calls as "detected" out of 5 comparison experiments in parentheses.