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. 2026 Apr 17;26:169. doi: 10.1186/s12902-026-02280-4

Table 2.

Association of TyG and its composite indices quartiles with cognitive function (Model1)

MOCA
Beta (95%CI)
DSST
Beta (95%CI)
AVLT-N3
Beta (95%CI)
AVLT-N5
Beta (95%CI)
TyG
 Quartile 1 Ref.
 Quartile 2 -0.43 (-1.11, 0.26) -0.85 (-3.35, 1.66) -0.27 (-1.25, 0.70) -0.23 (-2.12, 1.65)
 Quartile 3 -0.31 (-1.00, 0.39) -0.66 (-3.19, 1.87) -0.6 (-1.59, 0.39) -0.86 (-2.76, 1.03)
 Quartile 4 -0.81 (-1.51, -0.10) * -1.95 (-4.55, 0.64) -0.85 (-1.86, 0.16) -1.16 (-3.10, 0.78)
TyG-BMI
 Quartile 1 Ref.
 Quartile 2 -0.25 (-0.93, 0.44) 0.35 (-2.15, 2.85) -0.53 (-1.51, 0.45) -0.13 (-2.01, 1.76)
 Quartile 3 -0.65 (-1.35, 0.06) -0.96 (-3.56, 1.63) -0.84 (-1.84, 0.17) -1.15 (-3.08, 0.79)
 Quartile 4 -0.87 (-1.60, -0.14)* -2.10 (-4.79, 0.58) -0.76 (-1.80, 0.29) -1.02 (-3.03, 1.00)
TyG-WC
 Quartile 1 Ref.
 Quartile 2 0.01 (-0.67, 0.70) -0.06 (-2.58, 2.47) 0.31 (-0.67, 1.30) 0.61 (-1.29, 2.50)
 Quartile 3 -0.74 (-1.48, -0.01)* -2.22 (-4.93, 0.50) -0.33 (-1.38, 0.73) -0.07 (-2.10, 1.97)
 Quartile 4 -0.99 (-1.77, -0.21)* -1.51 (-4.39, 1.37) -0.69 (-1.81, 0.43) -1.23 (-3.38, 0.92)
TyG-WHtR
 Quartile 1 Ref.
 Quartile 2 -0.24 (-0.91, 0.44) -1.34 (-3.83, 1.15) -0.36 (-1.33, 0.61) -0.32 (-2.19, 1.55)
 Quartile 3 0.04 (-0.66, 0.73) -1.96 (-4.54, 0.61) -0.13 (-1.14, 0.87) 0.34 (-1.58, 2.26)
 Quartile 4 -1.35 (-2.07, -0.63)*** -3.70 (-6.36, -1.04)** -1.47 (-2.5, -0.44)** -2.46 (-4.44, -0.48)*
TyG-WWI
 Quartile 1 Ref.
 Quartile 2 0.26 (-0.41, 0.94) -0.48 (-2.96, 2.01) -0.23 (-1.19, 0.74) 0.17 (-1.70, 2.04)
 Quartile 3 0.05 (-0.65, 0.76) -1.89 (-4.48, 0.7) -0.02 (-1.03, 0.99) 0.64 (-1.30, 2.58)
 Quartile 4 -1.06 (-1.78, -0.33)** -2.9 (-5.57, -0.22)* -1.17 (-2.21, -0.13)* -1.71 (-3.70, 0.28)
TyG-ABSI
 Quartile 1 Ref.
 Quartile 2 0.06 (-0.63, 0.74) -1.18 (-3.68, 1.32) 0.33 (-0.65, 1.30) 0.59 (-1.29, 2.47)
 Quartile 3 -0.29 (-1.01, 0.43) -1.94 (-4.60, 0.71) -0.19 (-1.22, 0.84) 0.31 (-1.68, 2.30)
 Quartile 4 -0.93 (-1.68, -0.18)* -2.39 (-5.14, 0.36) -1.01 (-2.07, 0.06) -1.69 (-3.73, 0.36)

Notes: MoCA, Montreal Cognitive Assessment; DSST, Digit Symbol Substitution Test; AVLT-3, Auditory Verbal Learning Test-Immediate Recall Trial 3; AVLT-5, Auditory Verbal Learning Test-Delayed Recall; CI, confidence interval; TyG, triglyceride-glucose index; WHtR, waist-to-height ratio; BMI, body mass index; WC, waist circumference; WWI, weight-adjusted waist index; ABSI, a body shape index

Adjusted for gender and age

* p < 0.05; ** p < 0.01; *** p < 0.001