Table 3.
Subgroup analyses of the association between TyG and related obesity indices with cognitive function (Model1)
| Subgroup | Exposure | MoCA Beta (95%CI) |
DSST Beta (95%CI) |
AVLT-3 Beta (95%CI) |
AVLT-5 Beta (95%CI) |
|---|---|---|---|---|---|
| Gender | |||||
| Male | TyG | -0.06 (-0.45, 0.33) | 1.00 (-0.51, 2.52) | -0.14 (-0.76, 0.47) | -0.24 (-1.41, 0.94) |
| TyG-BMI | -0.00 (-0.01, 0.01) | 0.02 (-0.01, 0.05) | -0.00 (-0.01, 0.01) | -0.01 (-0.03, 0.02) | |
| TyG-WC | -0.00 (-0.00, 0.00) | 0.01 (-0.00, 0.02) | -0.00 (-0.00, 0.00) | -0.00 (-0.01, 0.01) | |
| TyG-WHtR | -0.17 (-0.57, 0.23) | 0.57 (-0.96, 2.09) | -0.18 (-0.81, 0.45) | -0.33 (-1.53, 0.87) | |
| TyG-WWI | -0.01 (-0.04, 0.02) | 0.01 (-0.09, 0.12) | -0.01 (-0.05, 0.03) | -0.02 (-0.10, 0.06) | |
| TyG-ABSI | -0.13 (-0.52, 0.25) | 0.37 (-1.10, 1.84) | -0.08 (-0.69, 0.52) | -0.18 (-1.33, 0.96) | |
| Female | TyG | -0.76 (-1.46, -0.05) | -2.27 (-4.72, 0.17) | -0.71 (-1.65, 0.23) | -0.81 (-2.62, 1.00) |
| TyG-BMI | -0.93 (-1.61, -0.25)* | -3.45 (-5.80, -1.11)* | -1.02 (-1.93, -0.12) | -1.68 (-3.41, 0.05) | |
| TyG-WC | -0.01 (-0.02, 0.00) | -0.05 (-0.09, -0.01) | -0.01 (-0.03, 0.01) | -0.01 (-0.04, 0.02) | |
| TyG-WHtR | -0.01 (-0.01, -0.00) | -0.02 (-0.03, -0.00) | -0.01 (-0.01, -0.00) | -0.01 (-0.02, 0.00) | |
| TyG-WWI | -0.07 (-0.12, -0.03)* | -0.22 (-0.38, -0.06)* | -0.08 (-0.15, -0.02)* | -0.13 (-0.25, -0.01) | |
| TyG-ABSI | -0.96 (-1.63, -0.30)* | -2.49 (-4.80, -0.17) | -1.21 (-2.10, -0.32)* | -1.76 (-3.47, -0.04) | |
| Age | |||||
| < 60 Years | TyG | -0.35 (-0.70, 0.01) | -0.77 (-2.24, 0.70) | -0.36 (-0.96, 0.23) | -0.43 (-1.55, 0.69) |
| TyG-BMI | -0.49 (-0.86, -0.13)* | -1.60 (-3.09, -0.11) | -0.54 (-1.14, 0.07) | -0.81 (-1.96, 0.34) | |
| TyG-WC | -0.01 (-0.01, 0.00) | -0.02 (-0.04, 0.01) | -0.01 (-0.02, 0.01) | -0.01 (-0.03, 0.01) | |
| TyG-WHtR | -0.00 (-0.01, 0.00) | -0.01 (-0.02, 0.00) | -0.00 (-0.01, 0.00) | -0.00 (-0.01, 0.00) | |
| TyG-WWI | -0.04 (-0.06, -0.01)* | -0.11 (-0.21, -0.01) | -0.04 (-0.08, 0.00) | -0.06 (-0.14, 0.02) | |
| TyG-ABSI | -0.47 (-0.81, -0.13)* | -1.28 (-2.69, 0.14) | -0.51 (-1.08, 0.06) | -0.74 (-1.82, 0.35) | |
| ≥ 60 Years | TyG | ||||
| TyG-BMI | -0.44 (-1.66, 0.77) | 2.31 (-0.98, 5.59) | -0.62 (-1.76, 0.52) | -1.26 (-3.53, 1.01) | |
| TyG-WC | -0.65 (-1.71, 0.41) | 0.54 (-2.33, 3.41) | -0.64 (-1.64, 0.37) | -1.53 (-3.53, 0.48) | |
| TyG-WHtR | -0.01 (-0.03, 0.01) | 0.03 (-0.03, 0.08) | -0.01 (-0.03, 0.01) | -0.03 (-0.07, 0.01) | |
| TyG-WWI | -0.00 (-0.01, 0.00) | 0.01 (-0.01, 0.03) | -0.00 (-0.01, 0.00) | -0.01 (-0.02, 0.00) | |
| TyG-ABSI | -0.05 (-0.12, 0.03) | 0.02 (-0.18, 0.22) | -0.04 (-0.11, 0.03) | -0.09 (-0.23, 0.05) | |
| BMI | |||||
| Non overweight | TyG | -0.49 (-1.02, 0.04) | -0.25 (-2.35, 1.85) | -0.74 (-1.49, 0.02) | -0.71 (-2.17, 0.75) |
| TyG-BMI | -0.69 (-1.33, -0.05) | -1.01 (-3.56, 1.54) | -1.18 (-2.09, -0.28) | -1.78 (-3.53, -0.02) | |
| TyG-WC | -0.01 (-0.02, 0.01) | 0.00 (-0.05, 0.06) | -0.02 (-0.04, 0.00) | -0.02 (-0.06, 0.02) | |
| TyG-WHtR | -0.00 (-0.01, 0.00) | -0.00 (-0.02, 0.01) | -0.01 (-0.01, 0.00) | -0.01 (-0.02, 0.00) | |
| TyG-WWI | -0.05 (-0.08, -0.01)* | -0.08 (-0.22, 0.06) | -0.07 (-0.12, -0.02)* | -0.10 (-0.20, 0.00) | |
| TyG-ABSI | -0.60 (-1.10, -0.11)* | -0.97 (-2.92, 0.99) | -0.94 (-1.64, -0.24)* | -1.23 (-2.58, 0.12) | |
| Overweight | TyG | -0.31 (-0.85, 0.24) | -0.98 (-2.80, 0.85) | -0.25 (-1.03, 0.53) | -0.73 (-2.19, 0.74) |
| TyG-BMI | -0.73 (-1.37, -0.09) | -2.49 (-4.62, -0.35) | -0.64 (-1.57, 0.28) | -1.44 (-3.18, 0.31) | |
| TyG-WC | -0.01 (-0.02, 0.00) | -0.02 (-0.07, 0.02) | -0.01 (-0.03, 0.01) | -0.03 (-0.06, 0.01) | |
| TyG-WHtR | -0.00 (-0.01, 0.00) | -0.01 (-0.02, 0.00) | -0.00 (-0.01, 0.00) | -0.01 (-0.02, 0.00) | |
| TyG-WWI | -0.04 (-0.08, 0.00) | -0.16 (-0.28, -0.03)* | -0.03 (-0.09, 0.02) | -0.07 (-0.17, 0.03) | |
| TyG-ABSI | -0.48 (-1.00, 0.05) | -1.63 (-3.39, 0.13) | -0.29 (-1.04, 0.47) | -0.77 (-2.20, 0.65) |
Notes: MoCA, Montreal Cognitive Assessment; DSST, Digit Symbol Substitution Test; AVLT-3, Auditory Verbal Learning Test-Immediate Recall Trial 3; AVLT-5, Auditory Verbal Learning Test-Delayed Recall; CI, confidence interval; TyG, triglyceride-glucose index; WHtR, waist-to-height ratio; BMI, body mass index; WC, waist circumference; WWI, weight-adjusted waist index; ABSI, a body shape index
Subgroup analyses were performed by gender, age (< 60 years/≥60 years) and BMI status (non-overweight: BMI < 24 kg/m²; overweight: BMI ≥ 24 kg/m²)
Adjusted for gender and age
* p < 0.05; ** p < 0.01