Table 1.
Patient characteristics of individuals with operable breast cancer or asymptomatic carriers of BRCA1 pathogenic variants.
| Age at genetic testing (y.o.) | Age at diagnosis of breast cancer (y.o.) | Stage at diagnosis | Subtype | Breast surgery (y.o.): right/left | Breast reconstruction: right/left | RRSO (y.o.) | |
|---|---|---|---|---|---|---|---|
| 1 | 25 | (−) | (−) | (−) | (−)/(−) | (−)/(−) | (−) |
| 2 | 37 | 37 | IIIC | ER+/HER2− | CRRM (37)/mastectomy (37) | (−)/(−) | 39 |
| 3 | 38 | 38 | I | ER+/HER2− | (−)/breast conserving surgery (38) | (−)/(−) | (−) |
| 4 | 38 | 38 | IIA | ER+/HER2− | CRRM (40)/mastectomy (38) | (−)/(−) | 39 |
| 5 | 45 | 41 | IIA | ER+/HER2− | (−)/mastectomy (41) | (−)/(−) | (−) |
| 45 | 45 | I | ER−/HER2− | Mastectomy (45)/(−) | (−)/(−) | 45 | |
| 6 | 47 | 47 | 0 | ER+ | CRRM (47)/nipple-sparing mastectomy (47) | (+)/(+) | 47 |
| 7 | 51 | 51 | IIA | ER−/HER2− | (−)/mastectomy (52) | (−)/(−) | (−) |
| 8 | 53 | 53 | IIA | ER+/HER2− | CRRM(53)/mastectomy(53) | (−)/(−) | 54 |
| 9 | 63 | (−) | (−) | (−) | (−)/(−) | (−)/(−) | (−) |
Case 5, who underwent genetic testing at age 45, was a single individual with a history of metachronous bilateral breast cancer.
RRSO, risk-reducing salpingo-oophorectomy; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; CRRM, contralateral risk-reducing mastectomy.