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. 2026 Apr 10;16:16934. doi: 10.1038/s41598-026-46000-3

Table 1.

Baseline patient characteristics.

Characteristics All
(3602)
No outcome
(N = 2906)
Outcome
(N = 696)
P value
Sex (Female), N (%) 2838 (78.8) 2242 (77.2) 596 (85.6) 0.22
Age group, N (%)
 18–29 68 (1.9) 61 (2.1) 7 (1.0) 0.4598
 30–39 199 (5.5) 182 (6.3) 17 (2.4) 0.6932
 40–49 419 (11.6) 358 (12.3) 61 (8.8) 0.1107
 50–59 1209 (33.5) 953 (32.8) 256 (36.8) 0.1001
 60–69 928 (25.8) 752 (25.8) 176 (25.3) 0.9857
 70–79 602 (16.7) 470 (16.2) 132 (18.9) 0.0831
 Over 80 177 (4.9) 130 (4.5) 47 (6.8) 0.8071
General comorbidities
 Diabetes mellitus 164 (4.6) 130 (4.5) 34 (5.0) 0.03
 Obesity 7 (0.2) 6 (0.2) 1 (0.1) 0.42
 Osteoarthritis 441 (12.2) 339 (11.7) 102 (14.7) 0.09
 Rheumatoid arthritis 21 (0.6) 16 (0.5) 5 (0.7) 0.23
 Depressive disorder 84 (2.3) 66 (2.3) 18 (2.6) 0.12
Medication use
 Antidepressants 1001 (27.8) 797 (27.4) 204 (29.3) 0.04
 Opioids 968 (26.9) 782 (26.9) 186 (26.7) < 0.001
 Antiinflammatory and antirheumatic 1555 (43.2) 1,252 (43.1) 303 (43.5) < 0.001