Table 2.
Logistic regression of PCT, IL-6, and MR-ProADM combinations for sepsis and shock prediction
| Predictors | Sepsis vs. No Sepsis | Sepsis vs. Shock | ||||
|---|---|---|---|---|---|---|
| OR | CI | P value | OR | CI | P value | |
| (Intercept) | 0.12 | 0.03 – 0.34 | 0.001 | 0.02 | 0.00 – 0.06 | <0.001 |
|
| ||||||
| Elevated biomarkers* | ||||||
| 1 biomarker | 23.61 | 5.83 – 128.71 | <0.001 | 3.75 | 0.60 – 29.24 | 0.156 |
| 2 biomarkers | 183.33 | 35.55 – 1608.73 | <0.001 | 7.00 | 1.30 – 5.28 | 0.029 |
| 3 biomarkers | 1233.33 | 181.99 – 26334.56 | <0.001 | 27.8 | 6.50 – 193.10 | <0.001 |
|
| ||||||
| Observations | 246 (212 sepsis and 34 no sepsis) | 212 (194 sepsis and 18 shock) | ||||
|
| ||||||
| R2Tjur | 0.658 | 0.139 | ||||
OR: odds ratio; CI: Confidence Interval; IL-6: interleukin-6; MR-ProADM: Mid-regional pro-adrenomedullin; PCT: procalcitonin.
*
Elevated biomarkers in Part II and III according to cut-off values detailed in Supplementary Table S3. Bold values indicate statistically significant differences (p ≤ 0.05).