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The plaque formations in the brains of 6- and 12-month-old mice. Fourteen APP23 mice were OVX at 3 months of age. At age of 6 or 12 months, animals were killed and brains were prepared for immunohistochemistry. Shown is anti-Aβ (1-17) (6E10 clone antibody) immunostaining of sagittal brain sections from APP23 (n = 10; A and D), OVX APP23 (n = 7; B and E), and APP23/Ar+/- (n = 10; C and F) mice aged 6 (A-C) and 12 (D-F) months.
