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. 2005 Dec 19;102(52):19208–19213. doi: 10.1073/pnas.0506627102

Table 4. Comparison of i.v. to i.c.v. administration potencies for MDAN-21, MA-19, and morphine.

Ligand i.c.v. ED50, nmol (95% C.I.) i.v. ED50, nmol (95% C.I.) i.v./i.c.v. ratio
8 (MDAN-21) 0.08 (0.06–0.10) 3.3 (3.0–3.6) 41.3
11 (MA-19) 0.04 (0.03–0.05) 1.61 (1.29–1.92) 40.3
Morphine 4.1 (3.7–4.8) 168 (146–178) 41.0