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. 2005 Dec 14;102(52):19063–19068. doi: 10.1073/pnas.0509176102

Fig. 1.

Fig. 1.

Interaction of SLP-76 with Lck, PLC-γ1, and Itk in Jurkat and splenic T cells. (A and B) SLP-76 associates with Lck in Jurkat cells (A) and purified splenic T cells (B). (C) WT SLP-76 and SLP-76-Δ185–194 deletion mutant used to reconstitute J14 cells and SLP-76-/- mice. (D) Levels of SLP-76 protein in Jurkat, J14, and J14 cells transfected with WT SLP-76 or SLP-76-Δ185–194. (E) Baseline and TCR induced association of Lck, PLC-γ1, and Itk with WT SLP-76 in J14 cells transfected with WT SLP-76 or SLP-76-Δ185–194. (F) Pooled results from three experiments of PLC-γ1 and Itk association with SLP-76 (expressed in arbitrary units as the densitometric intensity ratio of PLC-γ1:SLP-76 and Itk:SLP-76) in J14/SLP-76WT and SLP-76Δ185–194 cells.