Fig. 7.

Hapten-induced contact hypersensitivity, serum immunoglobulins, and Ab response to OVA. (A) Groups of four mice were sensitized with oxazolone and challenged with hapten (right ear) or ethanol (left ear). The results represent the difference in thickness between hapten- and vehicle-challenged ears. (B) Serum Ig isotypes were determined on samples from 6- to 8-week-old mice (n = 6 per group). (C) Anti-OVA IgM, IgG1, and IgE Abs in the serum of mice immunized i.p. with 100 μg of OVA in alum (n = 6 per group). For clarity, SDs are not shown, but they were uniformly <10% of the mean.