Table 1. Methods for cluster analysis and effect on H/P coclustering.

Clustering	H/P cocluster	Neighboring cluster
Hierarchical
Average linkage	Yes	[L, LT, S, Sc]
Single linkage	Yes	[L, LT, S, Sc]
Complete linkage	Yes	S
Increase in sum of square	Yes	M
Median	Yes	[L, LT, S, Sc]
Centroid	No
Sum of squares	Yes	S
Mean proximity	Yes*	M
Flexible, β = –0.2	Yes	[L, LT, Car, S, Sc]
Nonhierarchical
SOM: GEDI	Yes

Same abbreviations as in Fig. 1. LT, lung tumors (without carcinoid).

^*H/P cluster invaded by two LT samples