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[Preprint]. 2026 May 25:2026.05.25.727703. [Version 1] doi: 10.64898/2026.05.25.727703

Fig. 4: Directional coordination dynamics are altered in schizophrenia and relate to cognitive and clinical function.

Fig. 4:

(a–g) Group contrasts (controls vs schizophrenia) from GLMs controlling for age, sex, scanner site, and head motion (FDR-corrected). (a) Mean dwell time (MDT) by state. (b) Fraction rate (FR; overall occupancy) by state. (c) Transition probabilities. (d) Stationary distribution (long-run state proportions). (e) Spectral gap (rate of convergence to stationarity). (f) Mixing time (steps to within tolerance of stationarity). (g) Entropy rate (average unpredictability of the next state). Asterisks indicate FDR-corrected significance (* p < 0.05, ** p < 0.01, *** p < 0.001 ). FB = feedback, FF = feedforward, INT = integrative. (h) Within-group associations from GLMs (FDR-corrected) linking coordination dynamics (MDT, FR, transitions, stationary distribution, spectral gap, mixing time, entropy rate) to cognitive and clinical measures (CMINDS domains, CPZ dose, PANSS positive/negative), controlling for the same covariates (CPZ associations included symptom scores in covariates). Coefficients are sign-coded; asterisks indicate FDR-significant effects. Collectively, these results indicate a reorganization of coordination dynamics, with systematic shifts toward increased integrative engagement and altered transition structure in schizophrenia, and clear links to symptom severity, medication exposure, and cognitive performance.