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. 2005 Dec 27;102(52):19186–19191. doi: 10.1073/pnas.0509735102

Fig. 3.

Fig. 3.

Cocaine-induced CBP recruitment and histone H4 acetylation are decreased at the fosB promoter, resulting in decreased fosB expression in CBP haploinsufficient mice. (A) Cocaine was less effective in inducing fosB in the mutant mice. Values were from the mice 2 h after injection of 30 mg/kg cocaine i.p. (n = 3 mice pairs, control, 1; cocaine, 0.448 ± 0.033; P < 0.01). (B and C) ChIP assays show that, 20 min after 30 mg/kg cocaine injection, there is a decrease in CBP recruitment to the fosB promoter in mutant mouse striatum compared to wild type (n = 3 in each group, wild type set at 1, mutant 0.31; P < 0.05, input DNA as control) (B) and a decrease in acetylated histone H4 at the fosB promoter (n = 3 in each group; wild type set at 1; mutant 0.67; P = 0.014, input DNA as control) (C). Data are expressed as mean ± SEM.