Table 2.
Population, epidemiology, and cost inputs used to estimate the burden of disease in children <5 years of age.
| Argentina | Mexico | Chile | Colombia | Brazil | |
|---|---|---|---|---|---|
| Population <5 | 3,668,251 (37) | 10,047,365 (38) | 1,166,146 (39) | 4,373,565 (40) | 12,704,860 (41) |
| Incidence per 100,000 | |||||
| IPD | 10.0 (22, 42) | 18.6 (22) | 13.3 (29) | 12 (30, 31)b | 21.0 (34) |
| Inpatient PNE | 329.7 (23) | 801.5 (28) | 340.0 (29) | 1,312.8 (30, 31)c | 3,433.0 (35) |
| Outpatient PNE | 123.2 (23) | 6,412.0 (27) | 15,227.8 (24) | 5,133.3 (30, 31)c | 3,643.1 (24) |
| OM | 8,493.0 (24) | 855.3 (27) | 16,260.0 (24) | 2,574.3 (30, 31)d | 761.2 (36) |
| % IPD presenting as meningitis | 23 (42) | 9 (14) | 17 (29) | 11 (11) | 45 (11) |
| % non-invasive disease attributable to S. pneumoniae (20) | 29.1 | 29.1 | 29.1 | 29.1 | 29.1 |
| CFRsa (%) | |||||
| Meningitis | 14.3 (24) | 14.7 (27) | 4.0 (29) | 26.0 (33) | 13.0 (34) |
| Bacteremia | 1.5 (25) | 4.5 (27) | 4.0 (29) | 14.0 (33) | 13.0 (34) |
| PNE | 3.5 (24) | 3.0 (27) | 0.5 (24) | 9.0 (33) | 1.0 (34) |
| Direct medical cost per disease (2023 $USD) | |||||
| Bacteremia | 3,530 (21) | 5,818 (43) | 608 (24) | 5,160 (44) | 567 (34) |
| Meningitis | 2,741 (21) | 10,853 (43) | 2,427 (24) | 7,305 (44) | 699 (34) |
| Inpatient PNE | 2,158 (21) | 4,245 (43) | 706 (24) | 1,275 (44) | 237 (34) |
| Outpatient PNE | 150 (21) | 336 (43) | 65 (24) | 43 (44) | 76 (34) |
| OM | 31 (21) | 2,602 (43) | 28 (24) | 25 (44) | 76 (34) |
| Indirect cost per disease (2023 $USD) | |||||
| IPD | 283 | 228 | 367 | 161 | 240 |
| Inpatient PNE | 291 | 180 | 306 | 147 | 160 |
| Outpatient PNE | 100 | 60 | 153 | 43 | 80 |
| OM | 20 | 12 | 31 | 9 | 16 |
OM, otitis media; CFR, case fatality rate; IPD, invasive pneumococcal disease; PNE, pneumonia; USD, United States dollar.
a
CFR for meningitis and bacteremia assumed to be the same if data only presented CFR for overall IPD.
b
ICD-10 codes: A39.0, A39.4, A39.9, A40.3, A41.3, A41.5, A41.8, A41.9, A49.2, A49.8, A49.9, B95.3, G00.0, G00.1, G00.2, G03.9.
c
ICD-10 codes: J13, J14, J15.6, J15.8, J15.9, J16.8, J18.0, J18.1, J18.8, J18.9, J22.
d
ICD-10 codes: H65.0-H65.4, H65.9-H66.4 L, H66.9.