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. 2026 May 21;14:1768403. doi: 10.3389/fped.2026.1768403

Table 4.

Estimated annual economic and societal burden due to pneumococcal disease cases attributable to the serotypes included in PCV10, PCV13, PCV15, and PCV20 (in million USD).

PCV13 NIP Countries PCV10 NIP Countries
Argentina Mexico Chile Colombia Brazil
Economic burdena
PCV10 serotypes $2.13 $8.73 $0.25 $1.89 $1.98
PCV13 serotypes $3.59 $87.28 $2.07 $19.60 $25.33
PCV15 serotypes $3.93 $87.28 $2.55 $19.60 $26.34
PCV20 serotypes $5.50 $122.44 $3.06 $20.35 $30.91
Societal burdenb
PCV10 serotypes $0.56 $0.59 $0.42 $0.39 $1.01
PCV13 serotypes $0.94 $5.91 $3.53 $4.00 $12.99
PCV15 serotypes $1.02 $5.91 $4.34 $4.00 $13.51
PCV20 serotypes $1.43 $8.29 $5.22 $4.15 $15.85

NIP, national immunization program; PCV, pneumococcal conjugate vaccine.

a

Economic burden inclusive of direct medical costs due to each pneumococcal disease state, including IPD, inpatient pneumonia, outpatient pneumonia, and OM.

b

Societal burden inclusive of indirect costs due productivity loss resulting from each pneumococcal disease state, including IPD, inpatient pneumonia, outpatient pneumonia, and OM.