4. Yield and Productivity for PQ-Catalyzed Reductive C–C Coupling in Continuous Flow Conditions .
| entry | res. time (min) | yield (%) | produc. (mmol h–1) |
|---|---|---|---|
| 1 | 10 | 8 | 0.19 |
| 2 | 20 | 15 | 0.18 |
| 3 | 60 | 45 | 0.18 |
| 4 | 120 | 85 | 0.17 |
| 5 | 120 | 82 | 0.16 |
| 6 | 120 | 83 | 0.41 |
a
Reaction Condition: 4-bromoacetophenone (0.1M); PQ (5 mol%); N-methylpyrrole (10 equiv.); DMSO as solvent; 4 mL coiled Reactor; 440 nm Kessil Lamps; Room Temperature (fan cooled).
b
GC yields.
c
Reaction was performed with recovered catalysts.
d
Reaction was performed on a 10 mL reactor by numbering up two 5 mL coils.