Table 4.

Reduced glutathione and nitric oxide levels in liver homogenates among different Schistosoma mansoni-infected mice groups, treated with praziquantel and dapagliflozin as mono- or combined therapy.

Mice groups	Reduced glutathione (µmol/g) a	Nitric oxide (µmol/g) a
Infected non-treated (n = 6)	2.75 ± 0.91	2.52 ± 0.36
DMSO (n = 5)	2.72 ± 0.75	2.66 ± 0.27
PZQ (n = 6)	2.88 ± 0.26 (+ 4.73)	2.82 ± 0.30 (+ 11.90)
DAPA (n = 5)	3.36 ± 2.17 (+ 22.18)	3.18 ± 0.79 (+ 26.19)
DAPA + PZQ (n = 6)	4.42 ± 1.04 (+ 60.73) *	4.06 ± 0.88 (+ 61.11) **
P-value	P= 0.103	P ≤ 0.001

^a Analysis of variance (ANOVA) test. Data are expressed as means ± standard deviation

Values enclosed between parentheses represent the percentage of increase, compared to infected non-treated group; + increase

DAPA: dapagliflozin; DMSO: dimethyl sulfoxide; PZQ: praziquantel

^* Significant difference against infected non-treated, DMSO-, and DAPA-treated groups at P˂ 0.05

^** Significant difference against infected non-treated, DMSO-, PZQ-, and DAPA-treated groups P˂0.05