Table 6.

Hepatic granuloma count and diameter among different Schistosoma mansoni-infected mice groups, treated with praziquantel and dapagliflozin as mono- or combined therapy.

Mice groups	Granuloma count a	Granuloma diameter (µm) a
Infected non-treated (n = 6)	24.06 ± 3.89	522.22 ± 50.18
DMSO (n = 5)	23.13 ± 2.23	506.67 ± 36.51
PZQ (n = 6)	12.50 (48.05) ± 7.91*	494.44 ± 32.77 (5.32)
DAPA (n = 5)	14.87 (38.20) ± 5.43 *	373.33 ± 36.51 (28.52) **
DAPA + PZQ (n = 6)	10.28 (57.27) ± 2.96*	377.78 ± 17.21 (27.66) **
P-value	P ≤ 0.001	P ≤ 0.001

^a Analysis of variance (ANOVA) test. Data are expressed as means ± standard deviation

Values enclosed between parentheses represent the percentage of reduction, compared to infected non-treated group

DAPA: dapagliflozin; DMSO: dimethyl sulfoxide; PZQ: praziquantel

^* Significant difference against infected non-treated, and DMSO-treated groups at P˂ 0.05

^** Significant difference against infected non-treated, DMSO-, and PZQ-treated groups at P˂ 0.001