Table 7.
Immunohistochemistry score of cleaved-caspase-3 expression among different Schistosoma mansoni-infected mice groups, treated with praziquantel and dapagliflozin as mono- or combined therapy.
| Cells | Score | Mice groups a | P-value | ||||
|---|---|---|---|---|---|---|---|
| Infected non-treated (n = 6) |
DMSO (n = 5) |
PZQ (n = 6) * |
DAPA (n = 5) *, ** |
DAPA + PZQ (n = 6) *, ** |
|||
| Hepatocytes | Trace | 6 (100%) | 5 (100%) | – | – | – | P ≤ 0.001 |
| Weak (1+) | – | – | 6 (100%) | 5 (100%) | 6 (100%) | ||
| Moderate (2+) | – | – | – | – | – | ||
| Strong (3+) | – | – | – | – | – | ||
| Inflammatory cells | Trace | – | – | – | – | – | |
| Weak (1+) | 6 (100%) | 5 (100%) | 6 (100%) | – | – | ||
| Moderate (2+) | – | – | – | – | – | ||
| Strong (3+) | – | – | – | 5 (100%) | 6 (100%) | ||
a Monte Carlo test. Data are expressed as number and percent
DAPA: dapagliflozin; DMSO: dimethyl sulfoxide; PZQ: praziquantel
* Significant difference against infected non-treated, and DMSO-treated groups at P˂ 0.01 (hepatocytes)
** Significant difference against infected non-treated, DMSO-treated, and PZQ-treated groups at P˂ 0.01(inflammatory cells)