Table 2.

Evaluation of the generative AI output.

Request	GenAI response
1	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CCND1, E2F1, CDKN2A
2	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CDKN2A, E2F1, CCND1
2	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CDKN2A, E2F1, CCND1
4	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CDKN2A, E2F1, CCND1
5	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CCND1, E2F1, CDKN2A
6	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CCND1, E2F1, CDKN2A
7	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CCND1, E2F1, CDKN2A
8	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CCND1, E2F1, CDKN2A
9	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CCND1, E2F1, CDKN2A
10	ATM, CDK2, CDK4, CDKN1A, MAPK14, MTOR, NR1H4, PCNA, RB1, SPI1, TP53, ZFP36L1, CDKN2A, E2F1, CCND1

GenAI was asked ten times which genes should be added to the network. 12 genes were taken over from the previous model generation (black), and 3 new genes were suggested by GenAI (bold). Setup: temperature = 0, top_p = 0 (prompt; Fig. S6 (supplement) was used).